HA is a major component of synovial fluid and cartilage. HA plays many key roles in the trophic status of the cartilage and in the regulation of the intra-articular environment. HA is responsible for the viscoelastic properties (shock-absorbing and lubricating abilities) of synovial fluid, which has a lower concentration in osteoarthritis joints than in healthy ones. The molecular weight of HA in the synovial fluid of patients with rheumatoid arthritis is similar to that of patients with other joint disease, and moderately but significantly lower than that of normal synovial fluid.

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